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Autoimmune disease

Multiple sclerosis (MS)

Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1)

In vitro and mouse studies suggest inhibiting MALT1 could help treat MS. In mice, knockout of Malt1 prevented development of experimental autoimmune encephalomyelitis (EAE) and decreased infiltration of T helper type 17 (Th17) cells into the brain and spinal cord compared with no knockout. In wild-type mice, injection of wild-type, autoreactive Th17 cells induced EAE, whereas injection of autoreactive, Malt1-/- Th17 cells did not. Next steps could include evaluating MALT1 inhibitors in an animal model of MS.

SciBX 5(46); doi:10.1038/scibx.2012.1201
Published online Nov. 29, 2012

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Brüstle, A. et al. J. Clin. Invest.; published online Nov. 1, 2012;
Contact: Tak W. Mak, The Campbell Family Cancer Research Institute at The Princess Margaret Cancer Centre, Toronto, Ontario, Canada