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Autoimmune disease

Autoimmune disease

Transmembrane protein 173 (STING; TMEM173)

Mouse studies suggest inhibiting STING could help treat autoimmune disease triggered by extracellular host DNA. Cellular uptake of excess self-DNA is thought to drive autoimmune diseases including lupus and polyarthritis. In polyarthritic mice lacking DNase II, knockout of the cytosolic DNA sensor Sting blocked the development of the disease and decreased inflammatory cytokine production compared with normal expression of Sting. Next steps could include blocking STING activity in additional models of autoimmune disease.

SciBX 5(45); doi:10.1038/scibx.2012.1177
Published online Nov. 15, 2012

Patent and licensing status undisclosed

Ahn, J. et. al. Proc. Natl. Acad. Sci. USA; published online
Nov. 6, 2012;
Contact: Glen N. Barber, University of Miami Miller School of Medicine, Miami, Fla.