Thursday, November 8, 2012
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Rat studies suggest
antagonizing IL-1 receptor in the brain could help prevent postoperative
cognitive dysfunction in older individuals. In aged rats subjected to a
laparotomy, brain infusion of an IL-1 receptor antagonist at the time of
surgery prevented postoperative cognitive deficits and neuroinflammation,
whereas intraperitoneal injection of the same antagonist did not. Next steps
could include developing a strategy capable of delivering an IL-1 receptor
antagonist into the CNS.
an IL-1 receptor antagonist from Amgen
Inc. and Swedish
Orphan Biovitrum AB, is marketed to treat rheumatoid
a recombinant protein with the heterodimeric IL-1 receptor linked to the Fc
portion of human IgG from Regeneron
Pharmaceuticals Inc., is marketed to treat NLR family
pyrin domain containing 3 (NLRP3;
periodic syndrome (CAPS).
At least four other companies have IL-1 receptor inhibitors in Phase II
testing or earlier to treat various indications.
Published online Nov. 8, 2012
Patent and licensing status
R.M. et al. J. Neurosci.; published online Oct. 17, 2012;
Contact: Ruth M. Barrientos, University of Colorado at Boulder,
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