Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Infectious disease

Malaria

Unknown

In vitro studies identified two fluoroalkylated g-lactams derived from 4-aminoquinoline that could help treat malaria. In a chloroquine-sensitive and a multidrug-resistant strain of Plasmodium falciparum, the two most potent compounds inhibited the parasite with nanomolar IC50 values. Mouse model studies to demonstrate in vivo oral efficacy of the lead γ-lactams are ongoing.

SciBX 5(44); doi:10.1038/scibx.2012.1162
Published online Nov. 8, 2012

Patent application filed; available for licensing from University of Lyon Science Transfer
Contact: Christine Duarte, University of Lyon, Lyon, France
e-mail:
christine.duarte@universite-lyon.fr

Cornut, D. et al. J. Med. Chem.; published online Oct. 29, 2012;
doi:10.1021/jm301076q
Contact: Maurice Medebielle, University of Lyon, Lyon, France
e-mail:
maurice.medebielle@univ-lyon1.fr
Contact: Jean-Philippe Bouillon, University and National Institute of Applied Sciences of Rouen, Mont Saint Aignan, France
e-mail:
jeanphilippe.bouillon@univ-rouen.fr