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Prostate cancer

MicroRNA-23b (miR-23b)

Patient sample and mouse studies suggest increasing miR-23b signaling could help treat prostate cancer. In patient samples, miR-23b expression was lower in prostate cancer tissue than in benign prostatic hyperplasia and normal tissue. In a mouse xenograft model of prostate cancer, intratumoral delivery of miR-23b decreased tumor growth compared with delivery of control miRNA. Next steps could include evaluating vehicles for targeted delivery of miR-23b in prostate cancer models.

SciBX 5(44); doi:10.1038/scibx.2012.1157
Published online Nov. 8, 2012

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Majid, S. et al. Cancer Res.;
published online Oct. 16, 2012;
Contact: Rajvir Dahiya, San Francisco VA Medical Center and University of California, San Francisco, Calif.