Thursday, July 24, 2014
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fluorescence imaging to detect retinoid condensations in age-related
macular degeneration (AMD)
Mouse studies suggest
two-photon fluorescence imaging can detect retinoid condensations that can
help diagnose retinal degeneration or aid the discovery of therapeutic agents
that protect the retina. Retinoids are intrinsically fluorescent molecules
that accumulate in the retinal pigmented epithelium (RPE) during aging and
have been associated with AMD. In a mouse model of light-induced retinal
degeneration, ex vivo eye imaging revealed accumulation of fluorescent
granules in the RPE, whereas no granules were detected in mice receiving retinylamine,
which has been shown to protect the retina from light-induced degeneration.
In a mouse model of AMD, in vivo eye imaging detected fluorescent
granules in the RPE, whereas no granules were detected in healthy mice. Next
steps include applying the technology for the detection of retinal pathology
and the development of new therapies to preserve vision in humans.
Published online July 24, 2014
Patented; additional patent
applications filed; licensing negotiations ongoing
Palczewska, G. et al.
Nat. Med.; published online June 22, 2014;
Contact: Krzysztof Palczewski, Polgenix Inc., Cleveland,
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