Thursday, July 24, 2014
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A protocol to induce in
vivo production of antigen-specific Treg cells
protocol to induce the production of antigen-specific Treg cells
could be useful for treating autoimmune disorders. In mouse models with
established multiple sclerosis (MS) and type 1 diabetes, sublethal
irradiation followed by vaccination with self-peptides and autologous
transplantation of macrophages increased apoptosis of autoreactive T and B
cells and expansion of self-peptide-specific Treg cells and
decreased severity of autoimmune disease compared with irradiation plus
control peptide or saline vaccination. Next steps include selection of
self-peptides suitable for human trials and design of a clinical protocol to
replicate the procedure in patients.
Published online July 24, 2014
Patent pending; available
Kasagi, S. et al. Sci.
Transl. Med.; published online June 18, 2014;
Contact: WanJun Chen, National Institutes of Health,
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