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A protocol to induce in vivo production of antigen-specific Treg cells

An irradiation-vaccination protocol to induce the production of antigen-specific Treg cells could be useful for treating autoimmune disorders. In mouse models with established multiple sclerosis (MS) and type 1 diabetes, sublethal irradiation followed by vaccination with self-peptides and autologous transplantation of macrophages increased apoptosis of autoreactive T and B cells and expansion of self-peptide-specific Treg cells and decreased severity of autoimmune disease compared with irradiation plus control peptide or saline vaccination. Next steps include selection of self-peptides suitable for human trials and design of a clinical protocol to replicate the procedure in patients.

SciBX 7(28); doi:10.1038/scibx.2014.844
Published online July 24, 2014

Patent pending; available for licensing

Kasagi, S. et al. Sci. Transl. Med.; published online June 18, 2014;
Contact: WanJun Chen, National Institutes of Health, Bethesda, Md.