Thursday, July 17, 2014
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Influenza A virus hemagglutinin
stem fragment to induce broadly neutralizing antibodies
In vitro and mouse studies suggest the influenza
A virus hemagglutinin stem fragment could help protect
against influenza virus infection. The fragment contained an isoleucine
zipper that produced H1HA10-Foldon, a trimeric hemagglutinin stem immunogen
that harbors about 95% of the epitope bound by the broadly neutralizing
In binding assays, sera obtained from mice immunized with H1HA10-Foldon
neutralized five different strains of influenza virus, whereas sera from mice
immunized with an inactivated virus did not. In mice, prophylactic
immunization with H1HA10-Foldon protected against lethal challenge with
influenza virus. Next steps include testing the immunogen with other
adjuvants and immunization regimes in mice and ferrets.
& Johnson's Crucell
N.V. unit has the hemagglutinin-targeting, broadly
neutralizing antibody CR6261 in Phase I trials to treat influenza.
SciBX 7(27); doi:10.1038/scibx.2014.811
Published online July 17, 2014
Patent application filed;
available for licensing from the Indian
Institute of Science
Mallajosyula, V.V.A. et
al. Proc. Natl. Acad. Sci. USA; published online
June 9, 2014;
Contact: Raghavan Varadarajan, Indian Institute of Science, Bangalore,
Contact: Xiaoping Liang, Merck Research Laboratories, West
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