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Chemically defined medium for generation of human cardiomyocytes from induced pluripotent stem (iPS) cells

A chemically defined medium for differentiating human iPS cells into cardiomyocytes could be useful for generating cell-replacement therapies for cardiac repair. The culture medium consists of RPMI 1640, l-ascorbic acid 2-phosphate and rice-derived recombinant human albumin. The medium was able to generate sheets of cardiomyocytes with a yield of up to 100 cardiomyocytes per human iPS cell. The resulting human cardiomyocytes were not fully differentiated but still showed cardiomyocyte-like electrophysiological behaviors and expressed multiple cardiomyocyte markers. Next steps could include optimizing the culture medium and associated protocols to further mature the cardiomyocytes.

SciBX 7(27); doi:10.1038/scibx.2014.809
Published online July 17, 2014

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Burridge, P.W. et al. Nat. Methods; published online June 15, 2014;
Contact: Joseph C. Wu, Stanford University School of Medicine, Stanford, Calif.
Contact: Paul W. Burridge,
same affiliation as above