Thursday, July 17, 2014
Publication and contact
Chemically defined medium
for generation of human cardiomyocytes from induced pluripotent stem (iPS)
A chemically defined medium
for differentiating human iPS cells into cardiomyocytes could be useful for
generating cell-replacement therapies for cardiac repair. The culture medium
consists of RPMI 1640, l-ascorbic
acid 2-phosphate and rice-derived recombinant human albumin. The medium was
able to generate sheets of cardiomyocytes with a yield of up to 100
cardiomyocytes per human iPS cell. The resulting human cardiomyocytes were
not fully differentiated but still showed cardiomyocyte-like
electrophysiological behaviors and expressed multiple cardiomyocyte markers.
Next steps could include optimizing the culture medium and associated
protocols to further mature the cardiomyocytes.
Published online July 17, 2014
Patent and licensing status
Burridge, P.W. et al.
Nat. Methods; published online June 15, 2014;
Contact: Joseph C. Wu, Stanford University School of
Medicine, Stanford, Calif.
Contact: Paul W. Burridge,
same affiliation as above
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