Thursday, June 19, 2014
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Labeled spherical nucleic
acid (SNA) nanoparticle conjugates to study cellular uptake mechanisms and
Cell culture studies with
labeled SNA nanoparticle conjugates could provide insights into cellular
trafficking and improve the design of these agents as drug delivery vehicles.
SNA nanoparticle conjugates consisting of a quantum dot core and a fluorescent
oligonucleotide shell were synthesized to track intracellular events
following uptake. In cultured mouse endothelial cells, the nanoparticles
trafficked from early endosomes to late endosomes without entering lysosomes
or Golgi bodies, while a small unquantifiable fraction reached the cytosol.
In the late endosome, nucleic acid was degraded and cleared from the cell,
but the core was retained. Next steps could include designing SNA
nanoparticle conjugates with biodegradable cores to minimize cellular toxicity.
Published online June 19, 2014
Patent and licensing status
Wu, X.A. et al. J. Am.
published online May 19, 2014;
Contact: Chad A. Mirkin, Northwestern University, Evanston, Ill.
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