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Drug platforms

In vitro condensation of human mesenchymal stem cells (MSCs) to aid in vivo formation of functional cartilage

In vitro studies suggest using human MSCs to form structures called condensed mesenchymal cell bodies (CMBs) can generate cartilage that could help promote joint regeneration and bone repair. In vitro, 2.5´105 human MSCs supplemented with transforming growth factor-b3 (TGFB3) formed CMBs within a few days. CMBs layered onto a porous, decellularized bone matrix developed into cartilage that had normal stiffness in five weeks. In an in vitro model of cartilage defect, the fused CMBs filled the defect and integrated with surrounding tissue. Next steps include using CMBs in animal models to generate cartilage and bone grafts and initiating pre-IND discussions with the FDA.

SciBX 7(22); doi:10.1038/scibx.2014.661
Published online June 5, 2014

Covered by pending and filed patents; available for licensing

Bhumiratana, S. et al. Proc. Natl. Acad. Sci. USA; published online April 28, 2014;
Contact: Gordana Vunjak-Novakovic, Columbia University, New York, N.Y.