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Drug platforms

Hematopoietic stem cells (HSCs) generated via
ex vivo dedifferentiation for transplant applications

A study in mice suggests HSCs generated ex vivo could be useful for transplantation. Ex vivo viral expression of a cocktail of transcription factors in myeloid or lymphoid progenitor cells caused dedifferentiation into an HSC-like state. After transplantation into myelo-ablated mice, the HSCs engrafted into bone, spleen and thymus and differentiated into the full range of blood cells. Next steps could include repeating the experiment with human cells in a humanized mouse model and testing the ability of induced HSCs to restore bone marrow and immune function in disease models.

SciBX 7(21); doi:10.1038/scibx.2014.627
Published online May 29, 2014

Patent pending; available for licensing

Riddell, J. et al. Cell; published online April 24, 2014;
Contact: Derrick J. Rossi, Harvard University, Cambridge, Mass.