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Native chemical ligation for generating reversible covalent peptide bonds

A new approach for generating reversible covalent peptide bonds could be useful for synthesizing pharmacological agents, such as therapeutic peptides. The approach uses chemoselective, native chemical ligation at the non-natural amino acid N-(methyl)-cysteine. The approach was used to form reversible peptide bonds between amino acids without the use of enzyme catalysis. Next steps include using the method to synthesize pharmacological agents.

SciBX 7(18); doi:10.1038/scibx.2014.537
Published online May 8, 2014

Patent application filed; available for licensing

Ruff, Y. et al. J. Am. Chem. Soc.; published online April 18, 2014;
Contact: Nicolas Giuseppone, University of Strasbourg, Charles Sadron Institute, Centre National de la Recherche Scientifique (CNRS), Strasbourg, France