Thursday, May 1, 2014
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reflectance microscopy for label-free myelin imaging
Studies in mice and human
samples suggest spectral confocal reflectance microscopy could be a
label-free method to image myelinated axons. In normal mice, repeated use of
spectral confocal reflectance microscopy with multiple wavelengths was able
to image myelinated axons at depths of up to 400 mM
and track changes in myelination during development. In mice with myelin
mutations or treated with a demyelinating agent, the imaging method captured
decreases in myelination that matched those captured using fluorescent label-based
imaging. In postmortem human brains, the imaging method captured myelinated
axons in a manner comparable to fluorescence microscopy. Next steps could
include validating the imaging technique in additional models.
Published online May 1, 2014
Patent and licensing status
Schain, A.J. et al. Nat.
Med.; published online March 30, 2014;
Contact: Jaime Grutzendler, Yale School of Medicine, New
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