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Spectral confocal reflectance microscopy for label-free myelin imaging

Studies in mice and human samples suggest spectral confocal reflectance microscopy could be a label-free method to image myelinated axons. In normal mice, repeated use of spectral confocal reflectance microscopy with multiple wavelengths was able to image myelinated axons at depths of up to 400 mM and track changes in myelination during development. In mice with myelin mutations or treated with a demyelinating agent, the imaging method captured decreases in myelination that matched those captured using fluorescent label-based imaging. In postmortem human brains, the imaging method captured myelinated axons in a manner comparable to fluorescence microscopy. Next steps could include validating the imaging technique in additional models.

SciBX 7(17); doi:10.1038/scibx.2014.507
Published online May 1, 2014

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Schain, A.J. et al. Nat. Med.; published online March 30, 2014;
Contact: Jaime Grutzendler, Yale School of Medicine, New Haven, Conn.