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benthamiana to produce glycosylated IgMs
benthamiana could generate glycosylated IgMs to treat human diseases. In
engineered N. benthamiana plants lacking plant-specific glycosylation,
transfection with vectors encoding IgM components resulted in the production
of a therapeutic IgM, PAT-SM6,
in high picomolar yields per gram of plant material. The glycosylation
pattern of the plant-generated PAT-SM6 was comparable to that of PAT-SM6 produced
in a human cell line. In a human lung cancer cell line, the plant- and human
cell line-generated forms of PAT-SM6 showed comparable inhibitory action
against their target, heat shock
70 kDa protein 5 (glucose-regulated
protein, 78 kDa; HSPA5;
Next steps include using the engineered plants to generate IgMs against
antibiotic-refractory bacterial infections.
Patrys Ltd. has
PAT-SM6, a human mAb that binds HSPA5 and imports low-density
lipoprotein into cancer cells, in Phase I/II testing to treat
multiple myeloma (MM) and Phase I trials to treat melanoma.
Patrys, AstraZeneca plc
and Debiopharm Group
a human IgM mAb that binds to gastric cancer cells expressing CD55SC-1,
in Phase I/II testing to treat gastric cancer and in preclinical development
for solid tumors.
Published online May 1, 2014
Patented; licensing status
Loos, A. et al. Proc.
Natl. Acad. Sci. USA; published online March 31, 2014;
Contact: Herta Steinkellner, University of Natural Resources
and Applied Life Sciences, Vienna, Austria
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