Licensing status

Publication and contact information

Disease models

Humanized mice to model chronic HBV infection

Mice with humanized immune and liver cells could be used to model chronic HBV infection. In mice with engrafted human hepatocytes and leukocytes, inoculation with HBV+ patient serum caused chronic liver fibrosis and inflammation. In sera from 75% of the mice, detectable viral DNA persisted for 4 months. In the model, combined inoculation with the HBV+ sera and an anti-HBV antibody prevented infection. Next steps include using the model to identify HBV therapeutics.

SciBX 7(16); doi:10.1038/scibx.2014.472
Published online April 24, 2014

Patent application filed covering the humanized mouse models; licensing discussions under way

Bility, M.T. et al. PLoS Pathog.; published online March 20, 2014;
Contact: Lishan Su, The University of North Carolina at Chapel Hill, Chapel Hill, N.C.
Contact: Moses T. Bility, same affiliation as above