Thursday, April 24, 2014
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Assays & screens
Detection of Plasmodium
falciparum or Trypanosome infection with ultrasound-based separation of
red blood cells (RBCs)
separation technique could help detect low levels of parasitemia. The
densities of RBCs infected with
P. falciparum are known to be lower than those of uninfected RBCs. A
handheld device was constructed that exposed a human blood droplet to
ultrasonic waves to induce density-based separation of infected RBCs and
allow for sample extraction for microscopic analysis. Compared with no
separation, the technique increased infected cell levels in samples by over
100-fold and enabled detection of Trypanosoma cyclops and the ring
stage of P. falciparum at levels corresponding to 6 parasites/mL and
25 parasites/mL. Ongoing work includes optimizing the technology
for P. falciparum detection.
Published online April 24, 2014
Patented by the University of Glasgow;
licensed to SAW Dx Ltd.
Bourquin, Y. et al.
Angew. Chem. Int. Ed.; published online March 26, 2014;
Contact: Jonathan M. Cooper, University of Glasgow, Glasgow,
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