Thursday, April 17, 2014
Publication and contact
Mice with directed
integration of human immunoglobulin transgenes to produce chimeric antibodies
with fully human variable domains
Transgenic mice that
produce chimeric antibodies with human variable domains could be used for
therapeutic antibody discovery. Previous development of transgenic mice with
humanized immunoglobulins was limited by size of and random integration of
human transgenes. In mouse embryonic stem cells, the entire human
immunoglobulin variable-gene repertoire was inserted into the corresponding
mouse loci using bacterial artificial chromosome-based targeting vectors. The
resulting transgenic mice had functional immune systems that, when inoculated
with human IL-6
produced antibodies with a wide range of binding affinities for the antigen.
Ongoing work includes testing in clinical studies a high-affinity anti-CD126
antibody in which the mouse constant domain has been exchanged with the human
Published online April 17, 2014
licensed to Astellas Pharma Inc.
to use the mice to discover human mAbs; partnership with Sanofi to
discover and commercialize human mAbs; Academic VelocImmune Investigators
Program established to provide academics with access to the mice
Macdonald, L.E. et al.
Proc. Natl. Acad. Sci. USA; published online
March 25, 2014;
Murphy, A.J. et al. Proc. Natl. Acad. Sci. USA; published online March
Contact: Andrew J. Murphy, Regeneron Pharmaceuticals, Inc., Tarrytown,
Contact: George D. Yancopoulos, same affiliation as above
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]