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Drug platforms

Binary nylon-3 copolymers containing cationic and hydrophobic subunits for antimicrobial activity

In vitro studies identified binary nylon-3 copolymers containing cationic and hydrophobic subunits that could help treat and prevent bacterial infections. Nylon-3 copolymers were designed to mimic antibacterial host-defense peptides by modulating the arrangement of backbone components and subunits. The copolymer with the highest potency against prokaryotic cells versus eukaryotic cells showed strong antibacterial activity against Escherichia coli and methicillin-resistant Staphylococcus aureus. Resistance against the copolymer was not observed through 10 cell-culturing passages. Next steps include evaluating the polymers as antimicrobial agents on surfaces of implantable devices.

SciBX 7(15); doi:10.1038/scibx.2014.441
Published online April 17, 2014

Patent applications filed covering polymers; available for licensing

Liu, R. et al. J. Am. Chem. Soc.; published online March 7, 2014;
Contact: Samuel H. Gellman, University of Wisconsin-Madison, Madison, Wis.
Contact: Kristyn S. Masters, same affiliation as above