Thursday, April 17, 2014
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copolymers containing cationic and hydrophobic subunits for antimicrobial
In vitro studies identified binary nylon-3 copolymers
containing cationic and hydrophobic subunits that could help treat and
prevent bacterial infections. Nylon-3 copolymers were designed to mimic
antibacterial host-defense peptides by modulating the arrangement of backbone
components and subunits. The copolymer with the highest potency against
prokaryotic cells versus eukaryotic cells showed strong antibacterial
activity against Escherichia coli and methicillin-resistant
Staphylococcus aureus. Resistance against the copolymer was not
observed through 10 cell-culturing passages. Next steps include evaluating
the polymers as antimicrobial agents on surfaces of implantable devices.
Published online April 17, 2014
Patent applications filed
covering polymers; available for licensing
Liu, R. et al. J. Am.
Chem. Soc.; published online March 7, 2014;
Contact: Samuel H. Gellman, University of Wisconsin-Madison,
Contact: Kristyn S. Masters, same affiliation as above
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