Approach

Summary

Licensing status

Publication and contact information

Assays & screens

Protein misfolding cyclic amplification (PMCA) technique to create a-synuclein (SNCA) aggregates for drug screening

In vitro studies suggest SNCA aggregates formed using PMCA could be used to screen antiaggregating agents for Parkinson's disease (PD). The technique uses cycles of incubation to grow fibrils and cycles of sonication to break fibrils. The method resulted in faster formation of SNCA aggregates than traditional techniques, and drugs known to block aggregation were effective in the assay. Next steps could include using the approach to develop a cellular assay for screening.

SciBX 7(14); doi:10.1038/scibx.2014.410
Published online April 10, 2014

Findings unpatented; available for licensing and partnerships

Herva, M.E. et al. J. Biol. Chem.; published online Feb. 28, 2014;
doi:10.1074/jbc.M113.542340
Contact: Maria Grazia Spillantini, University of Cambridge,
Cambridge, U.K.
e-mail:

mgs11@cam.ac.uk
Contact: Maria Eugenia Herva, same affiliation as above
e-mail:

meh67@cam.ac.uk