Thursday, March 20, 2014
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Assays & screens
Plasma lipid signature to
identify presymptomatic individuals that may progress to Alzheimer's disease
Clinical data suggest
plasma lipids could help identify presymptomatic individuals who will develop
AD or mild cognitive impairment (MCI). The 5-year study included 46 patients
who already had AD or MCI, 28 initially unaffected individuals who were diagnosed
with AD or MCI during the study and 73 unaffected age-matched controls. In
plasma samples from the participants, lipidomics analysis identified a panel
of 8 phosphatidylcholines and 2 acylcarnitines that predicted the conversion
of unaffected patients to diagnosis with AD or MCI with 90% sensitivity and
90% specificity. A forthcoming manuscript will report the results of
transcriptomic and genomic analyses of plasma samples from the same cohort (see
lipids: harbingers of AD?, page 9).
Published online March 20, 2014
Patented by the University of Rochester
and Georgetown University;
Mapstone, M. et al. Nat.
Med.; published online March 9, 2014;
Contact: Howard J. Federoff, Georgetown University,
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