Thursday, March 13, 2014
Publication and contact
Assays & screens
Measurement of b-amyloid (Ab) oligomers
in cerebrospinal fluid (CSF) to diagnose and monitor the progression of
Alzheimer's disease (AD)
An assay that measures Ab
oligomers levels in CSF could help diagnose AD and monitor disease
progression in patients. An ELISA using an anti-Ab
oligomer mAb detected Ab oligomers in CSF at levels as low as 0.09
picograms/mL. In CSF from patients with AD, Ab oligomer
levels were higher than those in CSF from healthy controls and patients with
Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) or
schizophrenia. In patients with AD, Ab oligomer levels
correlated with disease severity as measured by mini-mental state examination
(MMSE) scores. Next steps could include testing diagnostic applications of
the assay in a larger cohort of patients with AD.
Published online March 13, 2014
Patent and licensing status
Savage, M.J. et al. J.
Neurosci.; published online Feb. 19, 2014;
Contact: Mary J. Savage, Merck & Co. Inc., West Point, Pa.
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