Thursday, February 27, 2014
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Computational modeling to
aid epitope-focused vaccine design
In silico, in vitro and primate studies suggest
computational modeling could aid epitope-focused vaccine design.
Computational design and screening identified stable epitope-presenting
protein scaffolds that mimicked an epitope in the respiratory
syncytial virus fusion protein (RSV F
protein) and specifically bound the RSV neutralizing
with comparable affinity to the natural epitope. Vaccination with the
scaffolds induced neutralizing antibodies in 12 of 16 rhesus macaques. Next
steps could include optimizing the vaccines for magnitude and durability of
discontinued development of the humanized anti-RSV F mAb motavizumab for RSV
prophylaxis in 2010.
Published online Feb. 27, 2014
Patent and licensing status
Correia, B.E. et al.
Nature; published online Feb. 5, 2014;
Contact: William R. Schief, University of Washington, Seattle,
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