Thursday, February 13, 2014
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Engineered Fc g-receptor
engagement enhances broadly neutralizing antibodies (bNAbs) against influenza
Mouse studies suggest bNAbs
engineered to activate Fc g-receptors on immune cells could help prevent
influenza infection. bNAbs that bind the invariant stalk region of hemagglutinin
were modified with Fc regions designed to bind a subset of Fc g-receptors
on immune cells that activate an antiviral response. In a mouse model of
lethal influenza infection, the engineered bNAbs increased survival and
decreased viral titers in the lung compared with antibodies containing Fc
regions that engaged inhibitory Fc g-receptors or were
deficient in Fc g-receptor binding. In humanized mice exclusively
expressing human Fc g-receptors, an engineered HA stalk-specific bNAb
increased survival after viral infection compared with an unmodified bNAb.
Next steps could include building Fc portions into therapeutic bNAbs that
enable interactions with activating Fc g-receptors in the
Published online Feb. 13, 2014
Patent and licensing status
DiLillo, D.J. et al.
published online Jan. 12, 2014;
Contact: Jeffrey V. Ravetch,
The Rockefeller University, New York, N.Y.
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