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Disease models

Gut microbe-associated phenotypes in mice receiving human fecal microbiota

A systems biology approach to studying mouse recipients of human gut microbes could aid the development of microbiota-associated disease models. Cultured fecal microbiota from a healthy human donor contained 17 different bacterial species. In gnotobiotic mice receiving 1 of 94 distinct combinations of up to 11 of the 17 species, systems-level analyses identified individual or groups of bacterial species that contributed to host phenotypes including colonic Treg populations, adiposity and gut levels of short-chain fatty acids. Future studies could include examining phenotypes in mice receiving cultured microbiota from patients with metabolic or intestinal diseases.

SciBX 7(6); doi:10.1038/scibx.2014.182
Published online Feb. 13, 2014

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Faith, J.J. et al. Sci. Transl. Med.;
published online Jan. 22, 2014;
Contact: Jeffrey I. Gordon, Washington University in St. Louis School of Medicine, St. Louis, Mo.