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2-Deoxy-2-[18F]fluoro-d-mannose ([18F]FDM) to image high-risk atherosclerotic plaques with PET

Cell culture and rabbit experiments suggest [18F]FDM can be used to image high-risk atherosclerotic plaques. Macrophages are common in high-risk lesions and express the macrophage mannose receptor (MR). In cultured human macrophages, [18F]FDM uptake was higher than [18F]fluoro-d-glucose ([18F]FDG) uptake. In a rabbit model of atherosclerosis, [18F]FDM labeled atherosclerotic lesions comparably in both in vivo and ex vivo imaging analyses. In the model, [18F]FDM uptake correlated with macrophage infiltration and was comparable to [18F]FDG uptake. Next steps include establishing methods for clinical-grade labeling of [18F]FDM and evaluating the reagent in human atherosclerotic plaques and carotid arteries.

SciBX 7(5); doi:10.1038/scibx.2014.157
Published online Feb. 6, 2014

Unpatented; licensing status not applicable

Tahara, N. et al. Nat. Med.; published online Jan. 12, 2014;
Contact: Jagat Narula, Icahn School of Medicine at Mount Sinai, New York, N.Y.