Thursday, February 6, 2014
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2-Deoxy-2-[18F]fluoro-d-mannose ([18F]FDM) to image
high-risk atherosclerotic plaques with PET
Cell culture and rabbit
experiments suggest [18F]FDM can be used to image high-risk
atherosclerotic plaques. Macrophages are common in high-risk lesions and
express the macrophage
mannose receptor (MR).
In cultured human macrophages, [18F]FDM uptake was higher than [18F]fluoro-d-glucose ([18F]FDG)
uptake. In a rabbit model of atherosclerosis, [18F]FDM labeled
atherosclerotic lesions comparably in both in vivo and ex vivo
imaging analyses. In the model, [18F]FDM uptake correlated with
macrophage infiltration and was comparable to [18F]FDG uptake.
Next steps include establishing methods for clinical-grade labeling of [18F]FDM
and evaluating the reagent in human atherosclerotic plaques and carotid
Published online Feb. 6, 2014
status not applicable
Tahara, N. et al. Nat.
Med.; published online Jan. 12, 2014;
Contact: Jagat Narula, Icahn School of Medicine at Mount
Sinai, New York, N.Y.
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