Thursday, February 6, 2014
Publication and contact
activating RNAs (saRNAs) to enhance CCAAT
enhancer binding protein-a (CEBPA)-dependent
gene expression in liver cancer
Cell culture and rat
studies suggest dendrimer-formulated saRNAs that bind target gene promoters
could help treat cancer. CEPBA-saRNA was conjugated to a triethanolamine core
poly(amidoamine) dendrimer for in vivo delivery. In a liver cancer
cell line, CEBPA-saRNA increased secretion of albumin and decreased cell
proliferation compared with a scrambled saRNA while maintaining hepatocyte
function. In a cirrhotic rat model with associated liver cancer, a
CEBPA-saRNA dendrimer conjugate increased levels of serum albumin and
decreased tumor burden compared with saline or scrambled saRNA-dendrimer,
suggesting improved liver function and antitumor activity. Next steps include
developing an saRNA-nanoparticle candidate for clinical trials (see RNA is for activation,
Published online Feb. 6, 2014
Patents filed; available
for licensing from MiNA
Contact: Robert Habib, MiNA
Therapeutics Ltd., London, U.K.
Reebye, V. et al.
Hepatology; published online Dec. 9, 2013;
Contact: Nagy A. Habib, Imperial College London, London, U.K.
Contact: Vikash Reebye, same affiliation as above
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]