Thursday, February 6, 2014
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Assays & screens
Multiplexed detection of
proteins in fine-needle aspirates
A method of profiling
multiple proteins in fine-needle aspirates could help monitor tumor responses
to therapy. Human cancer cells were incubated with a cocktail of 90
antibodies, each tagged with a different nonhuman DNA barcode. Photocleavage
and detection of the barcodes provided a readout on the expression of each
target protein. In fine-needle aspirates from primary tumors, the method
identified treatment-associated changes in tumor protein profiles in four
patients who received phosphoinositide
inhibitors. Planned work includes using the method to monitor treatment
responses in clinical trials of cancer therapies. The DNA barcode detection
system used in this study is manufactured by NanoString
Published online Feb. 6, 2014
Patented by Massachusetts
General Hospital; licensed to NanoString Technologies
Ullal, A.V. et al. Sci.
Transl. Med.; published online Jan. 15, 2014;
Contact: Ralph Weissleder, Massachusetts General Hospital,
Contact: Cesar M. Castro, same affiliation as above
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