Thursday, January 16, 2014
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electrochemical detector for in vivo continuous monitoring (MEDIC) of
MEDIC may allow real-time,
continuous monitoring of therapeutics in patients. MEDIC relies on an
electrochemical, aptamer-based sensor. In live rats with blood drawn into a
detection chip over 4.5 hours via a catheter, a doxorubicin-specific
aptamer probe responded dose dependently to the chemotherapeutic but did not
respond to vehicle. In a similar rat model, a kanamycin-specific
aptamer probe had a dose-dependent response to the compound. Next steps could
include adapting MEDIC for longer-term operation over days or weeks and
testing whether MEDIC can improve clinical outcomes by allowing personalized
Published online Jan. 16, 2014
Patent and licensing status
Ferguson, B.S. et al.
Sci. Transl. Med.; published online Nov. 27, 2013;
Contact: Hyongsok Tom Soh, University of California, Santa
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