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Microfluidic electrochemical detector for in vivo continuous monitoring (MEDIC) of therapeutics

MEDIC may allow real-time, continuous monitoring of therapeutics in patients. MEDIC relies on an electrochemical, aptamer-based sensor. In live rats with blood drawn into a detection chip over 4.5 hours via a catheter, a doxorubicin-specific aptamer probe responded dose dependently to the chemotherapeutic but did not respond to vehicle. In a similar rat model, a kanamycin-specific aptamer probe had a dose-dependent response to the compound. Next steps could include adapting MEDIC for longer-term operation over days or weeks and testing whether MEDIC can improve clinical outcomes by allowing personalized dosing.

SciBX 7(2); doi:10.1038/scibx.2014.73
Published online Jan. 16, 2014

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Ferguson, B.S. et al. Sci. Transl. Med.; published online Nov. 27, 2013;
Contact: Hyongsok Tom Soh, University of California, Santa Barbara, Calif.