Thursday, January 16, 2014
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Generation of metanephric
nephron progenitor cells from pluripotent stem cells for 3D kidney modeling in
Induced metanephric nephron
progenitor cells could help model kidney diseases. In mouse embryonic stem
cells (ESCs) or human induced pluripotent stem (iPS) cells, a differentiation
protocol was used to produce cells expressing metanephric nephron progenitor
markers, and these cells formed renal tubules and glomeruli in culture. The
protocol involved culturing cells with fibroblast
growth factor 5 (FGF5), bone
morphogenetic protein 4 (BMP4)
and a wingless-type
MMTV integration site (WNT)
agonist and then inducing expression of marker genes including caudal
type homeobox 2 (CDX2) and T-box 6
Next steps include creating a 3D kidney culture model by combining these
cells with induced ureteric bud progenitor cells.
Published online Jan. 16, 2014
Patent application filed;
available for licensing
Taguchi, A. et al. Cell
Stem Cell; published online Dec. 12, 2013;
Contact: Ryuichi Nishinakamura, Kumamoto University, Kumamoto,
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