Thursday, January 16, 2014
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A point-of-care device for
obtaining T cell counts from whole blood of HIV-infected individuals
A battery-powered, handheld
device for on-chip sample preparation and counting of CD4+ and CD8+ T cells from human whole blood samples could
provide point-of-care diagnostics for patients with HIV. Doctors routinely
measure CD4+ and CD8+ T cell levels
in patients with HIV to monitor the disease. Microfabrication methods were
used to generate a multilayered fluidic network capable of lysing and
quenching red blood cells, collecting and fluorescently tagging lymphocytes
and counting CD4+ or CD8+ T cells from
healthy individuals or patients with HIV. The counting error was estimated
using blood from healthy individuals and was 2.9% for CD4+ cells, 1.6% for CD8+ cells and 1.9% for the ratio. Next steps including
testing more samples from patients with HIV that have low CD4+ cell counts to determine the sensitivity and
robustness of the device.
Published online Jan. 16, 2014
Patent application filed;
available for licensing
Watkins, N.N. et al.
Sci. Transl. Med.; published online Dec. 4, 2013;
Contact: Rashid Bashir, University of Illinois at
Urbana-Champaign, Urbana, Ill.
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