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Assays & screens

Cancer diagnostics measuring the mechanical properties of cells

Human tissue studies suggest measuring the mechanical properties of cells could be used to diagnose cancer. Microfluidic mechanical manipulation of cells isolated from pleural fluid samples of 119 patients identified cell deformability differences that distinguished nonmalignant pleural effusions from malignant ones in 63% of the cases. Next steps include large-scale validation studies of mechanical deformation for hematological malignancies and inflammatory disease.
CytoVale Inc. has the microfluidic platform in preclinical development for the early detection of sepsis.

SciBX 7(1); doi:10.1038/scibx.2014.30
Published online Jan. 9, 2014

Patent pending; licensed to CytoVale

Tse, H.T.K. et al. Sci. Transl. Med.; published online Nov. 20, 2013;
Contact: Dino Di Carlo, University of California, Los Angeles, Calif.
Contact: Jianyu Rao, same affiliation as above