Thursday, January 9, 2014
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Assays & screens
measuring the mechanical properties of cells
Human tissue studies
suggest measuring the mechanical properties of cells could be used to
diagnose cancer. Microfluidic mechanical manipulation of cells isolated from
pleural fluid samples of 119 patients identified cell deformability
differences that distinguished nonmalignant pleural effusions from malignant
ones in 63% of the cases. Next steps include large-scale validation studies
of mechanical deformation for hematological malignancies and inflammatory
CytoVale Inc. has the
microfluidic platform in preclinical development for the early detection of
Published online Jan. 9, 2014
Patent pending; licensed to
Tse, H.T.K. et al. Sci.
Transl. Med.; published online Nov. 20, 2013;
Contact: Dino Di Carlo, University of California, Los
Contact: Jianyu Rao, same affiliation as above
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