Thursday, December 19, 2013
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Using innate immune markers
to detect early stage tumor recurrence
Mouse studies suggest
markers of the innate immune response could help detect early tumor
recurrence. In a mouse melanoma model in which T cell therapy was used to
eradicate tumors, cytokine analysis of skin samples showed Il-6
were elevated specifically at the time when latent tumor cells initiated
tumor recurrence but not prior to recurrence or after the formation of larger
tumors. In mice with different primary tumors, VEGF treatment induced early
recurrence of tumors from latent tumor cells that had not yet acquired
resistance, and these recurrent tumors were sensitive to therapy. Next steps
include developing a blood or urine test to detect early immune markers of
Published online Dec. 19, 2013
Patented; available for
Kottke, T. et al. Nat.
published online Nov. 17, 2013;
Contact: Richard Vile, Mayo Clinic, Rochester, Minn.
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