Thursday, December 19, 2013
Publication and contact
Using innate immune markers
to detect early stage tumor recurrence
Mouse studies suggest
markers of the innate immune response could help detect early tumor
recurrence. In a mouse melanoma model in which T cell therapy was used to
eradicate tumors, cytokine analysis of skin samples showed Il-6
were elevated specifically at the time when latent tumor cells initiated
tumor recurrence but not prior to recurrence or after the formation of larger
tumors. In mice with different primary tumors, VEGF treatment induced early
recurrence of tumors from latent tumor cells that had not yet acquired
resistance, and these recurrent tumors were sensitive to therapy. Next steps
include developing a blood or urine test to detect early immune markers of
Published online Dec. 19, 2013
Patented; available for
Kottke, T. et al. Nat.
published online Nov. 17, 2013;
Contact: Richard Vile, Mayo Clinic, Rochester, Minn.
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]