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SH3 and multiple ankyrin repeat domains 3 (Shank3; Prosap2; Spank-2)-overexpressing mice as a model of hyperkinetic neuropsychiatric disorders

Mice overexpressing Shank3 could provide a model of hyperkinetic neuropsychiatric disorders such as mania. Shank3-overexpressing, transgenic mice displayed 50% higher levels of total Shank3 protein than wild-type mice, and the protein was expressed in the same brain regions as endogenous Shank3. In open field tests, Shank3-overexpressing mice showed increased locomotor activity and speed compared with wild-type mice. The Shank3 transgenic mice also displayed signs of manic behavior, including increased amphetamine-induced hyperactivity, shorter duration of immobility in tail-suspension tests, increased acoustic response and decreased prepulse inhibition. Next steps could involve testing mood-stabilizing therapies in the transgenic mice.

SciBX 6(47); doi:10.1038/scibx.2013.1364
Published online Dec. 12, 2013

Unpatented; Shank3 mice available for licensing from the Baylor College of Medicine licensing group

Han, K. et al. Nature; published online Oct. 23, 2013;
Contact: Huda Y. Zoghbi, Baylor College of Medicine, Houston, Texas