Thursday, November 14, 2013
Publication and contact
Ferrous iron (FeII)-dependent
drug delivery system
Mouse studies suggest an FeII-dependent
delivery system could be useful for selectively targeting drugs to diseased
tissues. The system involves conjugating a drug to a linker molecule and a
1,2,4-trioxolane ring that undergoes fragmentation in the presence of FeII.
In Plasmodium berghei-infected mice, a conjugate carrying an
irreversible inhibitor of Plasmodium
dipeptidyl aminopeptidase 1
selectively targeted infected red blood cells and showed more persistent
inhibition of the parasitic enzyme than unconjugated inhibitor. In P.
berghei-infected mice, the conjugate decreased parasitemia and showed
increased safety compared with unconjugated inhibitor. Next steps include
developing an optimized version of the delivery system and evaluating it for
the delivery of drugs to treat malaria and cancer.
Published online Nov. 14, 2013
Patent application filed;
available for licensing from the University
of California, San Francisco Office of Innovation,
Technology & Alliances
Deu, E. et al. Proc.
Natl. Acad. Sci. USA; published online Oct. 21, 2013;
Contact: Matthew Bogyo, Stanford University School of
Medicine, Stanford, Calif.
Contact: Adam R. Renslo, University of California, San
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]