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Copper complex-based imaging agents to diagnose Alzheimer's disease (AD)

Studies in mice and human samples suggest copper complex-based imaging agents could help diagnose AD. In wild-type mice, microPET imaging showed that b-amyloid (Ab) plaque-targeted thiosemicarbazonato-pyridylhyseoxazine tetradentate ligands form a complex with a copper isotope and can cross the blood brain barrier and quickly dissipate when Ab plaques are absent. In brain tissue samples from patients with AD, the ligands bound to antibody-labeled Ab plaques, whereas they did not bind to tissue from healthy controls. Next steps could include testing the imaging agents in mouse models of AD.

SciBX 6(42); doi:10.1038/scibx.2013.1208
Published online Oct. 31, 2013

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Hickey, J.L. et al. J. Am. Chem. Soc.; published online Sept. 26, 2013;
doi:10.1021/ja4057807
Contact: Paul S. Donnelly,
The University of Melbourne, Melbourne, Victoria, Australia
e-mail:
pauld@unimleb.edu.au