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Detection of melanoma tumors with PET imaging using an 18F-labeled, melanin-binding small molecule

A PET agent derived from a melanin-binding small molecule could be useful for detecting metastatic melanoma tumors. Melanin is more highly expressed in melanoma tumors than in normal tissues. In a mouse model of melanoma, an 18F-labeled, melanin-binding iodoquinoxaline carboxamide showed greater uptake and retention in tumors than in normal tissues and plasma and was used to generate high-contrast PET images of tumors. Ongoing work in the mouse models includes testing an 131I-labeled carboxamide as follow-on radiotherapy to treat melanoma after tumors are detected with the 18F-labeled carboxamide.

SciBX 6(41); doi:10.1038/scibx.2013.1176
Published online Oct. 24, 2013

Patent and licensing status unavailable

Billaud, E.M.F. et al. J. Med. Chem.; published online Sept. 17, 2013;
doi:10.1021/jm400877v
Contact: Philippe Auzeloux, University of Auvergne, Clermont-Ferrand, France
e-mail:
philippe.auzeloux@inserm.fr