Thursday, October 3, 2013
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Mouse model of phosphoinositide
3-kinase catalytic subunit a-polypeptide (PIK3CA; p110a)-mutant, HER2 (EGFR2; ErbB2; neu)+ breast
A mouse model of HER2+
breast cancer with a PIK3CA mutation could be useful for developing
combination therapies to treat the disease. Mice with mammary epithelium-specific
overexpression of human HER2 and a mutant form of PIK3CA had tumors that grew
more aggressively and metastasized more readily than tumors with mammary
epithelium-specific overexpression of HER2 alone. In the mice, the HER2+,
PIK3CA-mutant tumors were resistant to the combination of anti-HER2
antibodies Herceptin trastuzumab and Perjeta pertuzumab. Next
steps include using these mice to test inhibitors of mutant PIK3CA in combination
with HER2 antagonists.
Roche's Genentech Inc. unit markets Herceptin to
treat metastatic breast and gastric cancers and Perjeta to treat metastatic
Published online Oct. 3, 2013
Patent and licensing status
Hanker, A.B. et al.
Proc. Natl. Acad. Sci. USA; published online Aug. 12, 2013;
Contact: Carlos L. Arteaga, Vanderbilt University, Nashville,
Contact: Jean J. Zhao, Harvard Medical School, Boston, Mass.
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