Thursday, October 3, 2013
Publication and contact
Assays & screens
mutagenesis screening to identify mutated genes that drive cancer
screening in mice could help identify genes that drive cancer when mutated.
Identifying oncogenic driver genes from high-copy transposon mutagenesis has
been difficult because of high background mutation rates. In mice, the
low-copy PB mutagenesis system, which generates about four insertion
mutations per tumor, was used to screen for drivers of mutant BRAF-expressing
melanoma growth. Sequencing identified insertions in 2 known melanoma
drivers, microphthalmia-associated transcription factor
(Mitf) and cyclin dependent kinase inhibitor 2A
(Cdkn2a; Ink4a; Arf; p16INK4a), and 36
previously undescribed candidate driver genes. Next steps could include using
the screening system for other types of cancer.
Published online Oct. 3, 2013
Patent and licensing
Ni, T.K. et al. Proc.
Natl. Acad. Sci. USA; published online Sept. 3, 2013;
Contact: Tian Xu, Yale School of Medicine, New Haven, Conn.
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