Thursday, September 19, 2013
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Induced pluripotent stem
(iPS) cell-derived, chimeric antigen receptor (CAR)-expressing
T cells for immunotherapy
CAR-expressing T cells could be used for immunotherapy in patients when
suitable autologous or allogeneic T cells are unavailable. In peripheral
blood T lymphocytes, viral vector-mediated expression of four factors
reprogrammed the cells into iPS cells. These iPS cells were then transduced
with a viral vector encoding a CD19-specific CAR and
differentiated into highly cytotoxic T lymphocytes. In a mouse model of
Burkitt's lymphoma, expanded, iPS cell-derived, CD19-specific CAR T
lymphocytes conferred a survival advantage comparable to that of parent
CD19-specific CAR T lymphocytes. Next steps include further optimization of
the method for generating iPS cell-derived, CAR-expressing T cells for
autologous or allogeneic therapies (see Supersizing adoptive T cell transfer,
Published online Sept. 19, 2013
Patent application filed;
available for licensing
Themeli, M. et al. Nat.
Biotechnol.; published online Aug. 11, 2013;
Contact: Michel Sadelain, Memorial Sloan-Kettering Cancer
Center, New York, N.Y.
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