Thursday, September 19, 2013
Publication and contact
Induced pluripotent stem
(iPS) cell-derived, chimeric antigen receptor (CAR)-expressing
T cells for immunotherapy
CAR-expressing T cells could be used for immunotherapy in patients when
suitable autologous or allogeneic T cells are unavailable. In peripheral
blood T lymphocytes, viral vector-mediated expression of four factors
reprogrammed the cells into iPS cells. These iPS cells were then transduced
with a viral vector encoding a CD19-specific CAR and
differentiated into highly cytotoxic T lymphocytes. In a mouse model of
Burkitt's lymphoma, expanded, iPS cell-derived, CD19-specific CAR T
lymphocytes conferred a survival advantage comparable to that of parent
CD19-specific CAR T lymphocytes. Next steps include further optimization of
the method for generating iPS cell-derived, CAR-expressing T cells for
autologous or allogeneic therapies (see Supersizing adoptive T cell transfer,
Published online Sept. 19, 2013
Patent application filed;
available for licensing
Themeli, M. et al. Nat.
Biotechnol.; published online Aug. 11, 2013;
Contact: Michel Sadelain, Memorial Sloan-Kettering Cancer
Center, New York, N.Y.
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]