Licensing status

Publication and contact information

Disease models

Mouse model of skin rash syndrome caused by anti-epidermal growth factor receptor (EGFR) therapy

A mouse model of anti-EGFR therapy-induced skin rash syndrome could be useful for developing treatment strategies. Mice were engineered with epidermal-specific knockout of Egfr. The mice developed progressive skin lesions that resembled those seen in patients being treated with anti-EGFR drugs. In the mouse model, localized macrophage depletion with clodronate-loaded liposomes partially reversed skin pathology compared with saline-loaded liposomes. Next steps include determining whether the anticancer effects of EGFR inhibitors are dependent on immunological mechanisms and evaluating new approaches to block macrophage function and infiltration in skin.
Bayer AG markets the bisphosphonate Bonefos clodronate outside the U.S. to treat tumor-induced osteolysis and hypercalcemia.

SciBX 6(36); doi:10.1038/scibx.2013.1009
Published online Sept. 19, 2013

Unpatented; model available for licensing

Mascia, F. et al. Sci. Transl. Med.; published online Aug. 21, 2013;
Contact: Stuart H. Yuspa, National Institutes of Health, Bethesda, Md.