Thursday, September 19, 2013
Publication and contact
Mouse model of skin rash
syndrome caused by anti-epidermal growth factor receptor (EGFR) therapy
A mouse model of anti-EGFR
therapy-induced skin rash syndrome could be useful for developing treatment
strategies. Mice were engineered with epidermal-specific knockout of Egfr.
The mice developed progressive skin lesions that resembled those seen in
patients being treated with anti-EGFR drugs. In the mouse model, localized
macrophage depletion with clodronate-loaded liposomes
partially reversed skin pathology compared with saline-loaded liposomes. Next
steps include determining whether the anticancer effects of EGFR inhibitors
are dependent on immunological mechanisms and evaluating new approaches to
block macrophage function and infiltration in skin.
Bayer AG markets the bisphosphonate
Bonefos clodronate outside the U.S. to treat tumor-induced
osteolysis and hypercalcemia.
Published online Sept. 19, 2013
Unpatented; model available
Mascia, F. et al. Sci.
Transl. Med.; published online Aug. 21, 2013;
Contact: Stuart H. Yuspa, National Institutes of Health, Bethesda,
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]