Thursday, September 19, 2013
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Mouse model of skin rash
syndrome caused by anti-epidermal growth factor receptor (EGFR) therapy
A mouse model of anti-EGFR
therapy-induced skin rash syndrome could be useful for developing treatment
strategies. Mice were engineered with epidermal-specific knockout of Egfr.
The mice developed progressive skin lesions that resembled those seen in
patients being treated with anti-EGFR drugs. In the mouse model, localized
macrophage depletion with clodronate-loaded liposomes
partially reversed skin pathology compared with saline-loaded liposomes. Next
steps include determining whether the anticancer effects of EGFR inhibitors
are dependent on immunological mechanisms and evaluating new approaches to
block macrophage function and infiltration in skin.
Bayer AG markets the bisphosphonate
Bonefos clodronate outside the U.S. to treat tumor-induced
osteolysis and hypercalcemia.
Published online Sept. 19, 2013
Unpatented; model available
Mascia, F. et al. Sci.
Transl. Med.; published online Aug. 21, 2013;
Contact: Stuart H. Yuspa, National Institutes of Health, Bethesda,
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