Thursday, September 5, 2013
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Transgenic, humanized mouse
model of HCV infection
immunocompromised, humanized mice could be used as a model of HCV infection
to help evaluate antiviral drug candidates. Transgenic mice with stable
expression of human CD81
in the liver supported HCV entry, but infection was limited to a single
cycle. In these transgenic mice, deletion of signal
transducer and activator of transcription 1 (Stat1)
rendered the animals partially immunocompromised and susceptible to HCV
entry, infection and replication. Next steps include selecting viral variants
that replicate more robustly in a series of mouse strains with progressively
compromised immune systems to establish a fully competent mouse model of HCV
LLC is in discussion with The Jackson
Laboratory to make the mouse model available to the
SciBX 6(34); doi:10.1038/scibx.2013.941
Published online Sept. 5, 2013
Use of OCLN in the mouse
model of HCV patented by Apath; available for licensing from Apath
Contact: Robert Roth, Apath LLC, St. Louis, Mo.
Dorner, M. et al. Nature;
published online July 31, 2013;
Contact: Alexander Ploss,
Princeton University, Princeton, N.J.
Contact: Charles M. Rice,
The Rockefeller University, New York, N.Y.
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