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Scavenger receptor class F member 1
(Scarf1)-deficient mouse model of systemic lupus erythematosus (SLE)

In vitro and mouse studies suggest Scarf1-/- mice could model SLE and aid the development of therapeutics for the disease. Impaired uptake of apoptotic cells by phagocytes contributes to inflammation and autoimmune diseases including SLE. In dendritic cells from Scarf1-/- mice, uptake of apoptotic cells by phagocytes was lower than that for dendritic cells from wild-type mice. In mice, Scarf1 knockout caused accumulation of apoptotic cells in tissues and circulation, immune cell activation, generation of autoantibodies and establishment of an SLE-like disease. Next steps could include using the model to identify new therapeutics for SLE.

SciBX 6(32); doi:10.1038/scibx.2013.874
Published online Aug. 22, 2013

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Ramirez-Ortiz, Z.G. et al. Nat. Immunol.; published online July 28, 2013;
Contact: Terry K. Means, Massachusetts General Hospital and Harvard Medical School, Charlestown, Mass.