Thursday, August 15, 2013
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vaccine to prevent tick-borne encephalitis (TBE)
A single-cycle virus
vaccine platform, RepliVax, could help generate vaccines
to protect against TBE. The single-cycle virus vaccine (RepliVax-TBE)
was constructed using a West Nile virus backbone with deletion of the capsid
gene and insertion of TBE virus envelope genes. In outbred mice,
intraperitoneal immunization with RepliVax-TBE induced a protective immune
response and increased survival against a lethal challenge with a TBE-related
virus compared with mock immunization. In nonhuman primates, a single dose of
RepliVax-TBE protected from challenge with a TBE-related virus and induced
more durable immune responses compared with an inactivated human TBE virus
vaccine. Next steps include evaluating the breadth of protection conferred by
RepliVax-TBE against circulating wild-type TBE strains representing three
Published online Aug. 15, 2013
Patented by Sanofi Pasteur; licensing status undisclosed
Rumyantsev, A.A. et al.
Proc. Natl. Acad. Sci. USA; published online July 15, 2013;
Contact: Konstantin V. Pugachev, Sanofi Pasteur, Discovery
US, Cambridge, Mass.
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