Thursday, August 15, 2013
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Assays & screens
Inner-ear hair cell
cultures generated from embryonic stem cells (ESCs) as a screening platform
for otology drugs
Inner-ear cell cultures
generated from ESCs could help identify drug compounds that are ototoxic or
promote inner-ear hair cell differentiation and regeneration. In serum-free
3D cultures of mouse ESCs, sequential treatment with cocktails of human
proteins and small molecule inhibitors induced differentiation into inner-ear
sensory epithelial cells. Electrophysiological, genetic and morphological
analyses classified the cells as type II vestibular hair cells, which aid in
sensing head position and movement. Ongoing studies include generating
cochlear hair cells from mouse ESCs and functional hair cell types from human
Published online Aug. 15, 2013
Patent application filed by
the Indiana University School of Medicine;
unavailable for licensing
Koehler, K.R. et al.
Nature; published online July 10, 2013;
Contact: Eri Hashino, Indiana University, Indianapolis, Ind.
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