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Disease models

Mouse model for prostate cancer driven by v-ets erythroblastosis virus E26 oncogene homolog (ERG) translocations

Mice with prostate-specific Erg expression could be used as a model to study prostate cancer pathogenesis. Translocations of ETS transcription factors including ERG are common in prostate cancer but have been difficult to model in mice. To develop a mouse model to study the role of ERG in prostate cancer, prostate-specific Erg overexpression was combined with homozygous loss of Pten (Mmac1; Tep1), which led to the development of invasive prostate adenocarcinomas in 80% of the animals at 6 months. In Pten-deficient prostates, Erg overexpression increased the expression of androgen receptor-regulated genes compared with wild-type Erg expression. Next steps could include using the model to identify new therapeutic targets.

SciBX 6(29); doi:10.1038/scibx.2013.770
Published online Aug. 1, 2013

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Chen, Y. et al. Nat. Med.; published online June 30, 2013;
Contact: Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center, New York, N.Y.

Contact: Yu Chen, same affiliation as above