Thursday, July 25, 2013
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Matrix metalloproteinase 9 (MMP9)-deficient
mice for modeling preeclampsia
Mouse fetuses and pregnant
mice lacking Mmp9 could be useful in identifying therapies to treat
preeclampsia. Maternal deficiencies in circulating MMP9 levels are
associated with human preeclampsia. In wild-type and Mmp9-deficient
pregnant mice, homozygous Mmp9 knockout embryos showed defects in
implantation and placental development similar to those observed in human
preeclampsia. In pregnant mice, homozygous Mmp9 knockouts showed
maternal symptoms of preeclampsia, including increased blood pressure and
proteinuria, whereas heterozygous Mmp9 knockouts and wild-type mice
did not. Future studies could include utilizing the models to screen
potential preeclampsia therapeutics.
Published online July 25, 2013
Patent and licensing status
Plaks, V. et al. Proc.
Natl. Acad. Sci. USA; published online June 17, 2013;
Contact: Zena Werb, University of California, San Francisco,
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