Thursday, June 20, 2013
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Peptidyl arginine deiminase type III (PADI3; PAD3)
autoantibodies as a prognostic marker for rheumatoid arthritis (RA)
Patient sample studies
suggest autoantibodies that recognize PAD3 and activate PAD4 (PADI4) could be used to
identify patients at risk for radiographic progression in RA. Autoantibodies
against PAD4 have previously been correlated with severe disease in patients
with RA, but there is heterogeneity within that group. In serum samples from
150 patients with RA, 80% of those with anti-PAD3 antibodies had radiographic
progression, whereas it was only 50% for those with no anti-PAD antibodies.
In this patient cohort, the presence of both anti-PAD3 and anti-PAD4
antibodies was associated with increased disease severity compared with the
presence of anti-PAD4 antibodies alone. Next steps include looking for
anti-PAD3 and anti-PAD4 antibodies in additional patient cohorts and
understanding the mechanism by which anti-PAD3 antibodies activate PAD4.
Published online June 20, 2013
Patent application filed;
licensing status undisclosed
Darrah, E. et al. Sci.
Transl. Med.; published online May 22, 2013;
Contact: Antony Rosen, The Johns Hopkins University School
of Medicine, Baltimore, Md.
Contact: Felipe Andrade, same affiliation as above
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