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Poly(carboxybetaine methacrylate) (PCBMA), zwitterionic hydrogels to coat implantable devices

Mouse studies identified PCBMA hydrogels that could be applied to implantable devices to prevent foreign body reactions. Foreign body reactions cause encapsulation of implanted devices in collagen capsules. In mice, collagen density around implanted PCBMA hydrogels was only 30%-40%, whereas around clinically available poly(2-hydroxyethyl methacrylate) (PHEMA) it was higher than 90% and accompanied by increased inflammation. Next steps could include testing the zwitterionic hydrogels as device coatings.

SciBX 6(22); doi:10.1038/scibx.2013.562
Published online June 6, 2013

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Zhang, L. et al. Nat. Biotechnol.; published online March 12, 2013;
Contact: Shaoyi Jiang, University of Washington, Seattle, Wash.