Thursday, May 30, 2013
This week in techniques
Publication and contact
Transferrin-coated, brain-penetrant gold nanoparticles
Mouse studies suggest
transferrin-coated gold nanoparticles could be useful for delivering
therapeutics across the blood brain barrier (BBB). Gold nanoparticles of
different diameters and transferrin content were synthesized. In mice,
nanoparticles with diameters of 40 nm or 80 nm and moderate transferrin
content bound to the transferrin receptor,
penetrated the BBB and accumulated in the brain parenchyma. In contrast, gold
nanoparticles with low transferrin content showed weak binding to the
transferrin receptor and failed to penetrate the BBB, whereas those with high
transferrin content bound to the receptor but were not released into the
brain parenchyma. Next steps include adapting the transferrin-based strategy
to polymeric nanoparticle technologies and exploring other nanoparticle
parameters that could be modulated to optimize delivery across the BBB (see
transferrin-mediated transcytosis, page 7).
Published online May 30, 2013
Patent application filed
covering methods to deliver nanoparticles to the brain; unavailable for
Wiley, D.T. et al. Proc.
Natl. Acad. Sci. USA; published online May 6, 2013;
Contact: Mark E. Davis, California Institute of Technology, Pasadena,
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]